P9‐73: Effects of dupilumab for severe eosinophilic asthma COPD overlap

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The Asthma-COPD Overlap Syndrome.

Although in textbooks asthma and chronic obstructive pulmonary disease (COPD) are viewed as distinct disorders, there is increasing awareness that many patients have features of both. This article reviews the asthma-COPD overlap syndrome.

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The Asthma-COPD Overlap Syndrome

Asthma and Chronic Obstructive Pulmonary Disease (COPD) are pulmonary disorders characterized by various degrees of airflow limitation, inflammation and tissue remodeling. Bronchial asthma, an allergic disease that develops in childhood, is physiologically characterized by reversible airflow obstruction. It has an episodic course and a generally favorable prognosis, as it responds well to anti-...

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Eosinophilic bioactivities in severe asthma

Asthma is clearly related to airway or blood eosinophilia, and asthmatics with significant eosinophilia are at higher risk for more severe disease. Eosinophils actively contribute to innate and adaptive immune responses and inflammatory cascades through the production and release of diverse chemokines, cytokines, lipid mediators and other growth factors. Eosinophils may persist in the blood and...

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Heterogeneity of asthma–COPD overlap syndrome

Many patients suffering from asthma or COPD have overlapping features of both diseases. However, a phenotypical approach for evaluating asthma-COPD overlap syndrome (ACOS) has not been established. In this report, we examined the phenotypes in patients with ACOS. Patients diagnosed with ACOS between 2011 and 2015 were identified and classified into four phenotype groups. Group A was composed of...

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ژورنال

عنوان ژورنال: Respirology

سال: 2021

ISSN: ['1440-1843', '1323-7799']

DOI: https://doi.org/10.1111/resp.14150_774